Numerous studies have shown that many users do not acquire the knowledge necessary for the effective and efficient use of computer applications such as spreadsheets and Web-authoring tools. While many cognitive, cultural, and social reasons have been offered to explain this phenomenon, there have been few systematic attempts to address it. This article describes how we identified a framework to organize effective and efficient strategies to use computer applications and used an approach called strategy-based instruction to teach those strategies over five years to almost 400 students. Controlled experiments demonstrated that the instructional approach (1) enables students to learn strategies without harming command knowledge, (2) benefits students from technical and nontechnical majors, and (3) is robust across different instructional contexts and new applications. Real-world classroom experience of teaching strategy-based instruction over several instantiations has enabled the appr.
See Full PDF See Full PDFProceedings of the SIGCHI conference on Human factors in computing systems the CHI is the limit - CHI '99
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Information Technology for …
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Thrombosis and Haemostasis
SummaryTransient procoagulant states resulting in failure of recanalization or rethrombosis of the reperfused artery during thrombolytic therapy might be due to an inhibitory effect of plasmin on the anticoagulant properties of protein C. We therefore studied the effect of plasmin on protein C (PC) and activated protein C (APC) using purified human proteins.Incubation of 70 nM purified human PC with 40-400 nM human plasmin resulted in rapid activation and subsequent inactivation of PC as measured by amidolytic and anticoagulant assays. The rates of activation and inactivation were dependent on the concentration of plasmin. Lower concentrations of plasmin resulted in higher peaks of generated APC and more sustained activity, while at higher concentrations, both activation and inactivation were more rapid. Anticoagulant activity appeared more sensitive to inactivation by plasmin than amidolytic activity; e. g., while amidolytic activity reached a maximum of 13.8 nM in 6 min and declin.
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International Journal of Technology and Design Education
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